Light‐Induced Dealkylation of Benzamides in Aqueous Solution

The N-dealkylation reactions of benzamides occur naturally in living organisms but chemical methods remain poorly developed. So far, light-induced variants these processes have been restricted to amides containing secondary N-alkyl groups or required pre-functionalization the starting material. Here, we present a direct, controllable tertiary and possessing primary alkyl substituents at N-atom. developed strategy operates aqueous environment under mild conditions involving either blue LEDs sunlight irradiation. Preliminary mechanistic studies indicate two-step oxidation intermediacy radicals α-position Selectivity homo- heterosubstituted is also investigated.